Gabe and Lexine attempt to make their escape but they find the airlock is locked and only accessible from a hackable console near the ship. Gabe chases after the two strange men to a docked ship, where Lexine escapes into the ship while her two kidnappers are transformed into Necromorphs which he quickly dispatches. Gabe is finally able to make it through the Hospital to the Psych Ward only to find Victor being disabled by two strange men claiming to have orders to capture Lexine for further study.

With renewed vigor, Gabe reaches the hospital in a gunship to try to get to Lexine before his superior officer can reach her. Gabe then demands an answer for his commander's seemingly random act of violence leading to the revelation that Gabe's wife Lexine is on the list of key subjects to terminate because of her involvement in the Oracle Program which has something to do with Lexine's recent pregnancy. After launching explosive canisters at the gunship, Gabe is able to force Victor to retreat.

Once Gabe finally arrives at the Titan Mines exit, he is fired upon by his superior officer, Victor Bartlett, who is in a gunship. During this, he receives a transmission from Director Tiedemann ordering all surviving security teams to scrub the facility and eliminate all key subjects. After his emergency warning is transferred, Gabe makes his way through the mines, passing through many areas that will be visited by Isaac Clarke. After Gabe's first encounter with the Necromorph outbreak in the Titan Mines and the death of the majority of his patrol squad, Gabe is able to contact Lexine to warn her of the outbreak.

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